Publications And Funding

Lab Publications

The genomic landscape of prostate cancer
Baca SC, Garraway LA. Front Endocrinol. 2012;3:69. Epub 2012 May 16.PubMed ID: 22649426

Melanoma genome sequencing reveals frequent PREX2 mutations
Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, Wagle N, Sucker A, Sougnez C, Onofrio R, Ambrogio L, Auclair D, Fennell T, Carter SL, Drier Y, Stojanov P, Singer MA, Voet D, Jing R, Saksena G, Barretina J, Ramos AH, Pugh TJ, Stransky N, Parkin M, Winckler W, Mahan S, Ardlie K, Baldwin J, Wargo J, Schadendorf D, Meyerson M, Gabriel SB, Golub TR, Wagner SN, Lander ES, Getz G, Chin L, Garraway LA.Nature 2012 May 9;485(7399):502-6.PubMed ID: 22622578

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, Macdonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA. Nat Genet. 2012 May [Epub ahead of print] PubMed ID: 22610119

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R , and Garraway LA. Nature. 2012 March 29;483(7391):603-607 PubMed ID: 22460905

High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing
Wagle N, Berger MF, Davis MJ, Blumenstiel B, DeFelice M, Pochanard P, Ducar M, Van Hummelen P, MacConaill LE, Hahn WC, Meyerson M, Gabriel SB, and Garraway LA. Cancer Discovery 2012 Jan; 2(1):82-93.PubMed ID: 22585170

RAS Mutations Are Associated With the Development of Cutaneous Squamous Cell Tumors in Patients Treated With RAF Inhibitors
Oberholzer PA, Kee D, Dziunycz P, Sucker A, Kamsukom N, Jones R, Roden C, Chalk CJ, Ardlie K, Palescandolo E, Piris A, Macconaill LE, Robert C, Hofbauer GF, McArthur GA, Schadendorf D, Garraway LA. J Clin Oncol. 2011 Nov 7. [Epub ahead of print] PubMed ID: 22067401

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence M, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D, Cortés ML, Auclair D, Berger MF, Saksena G, GuiducciC, Onofrio R, Parkin P, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K, Gabriel SB, Meyerson M, Lander ES, Getz G, Golub TR, Garraway LA, Grandis JR. Science. 2011 Aug 26;333(6046):1157-60 PubMed ID: 21798893

Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling
Wagle N, Emery C, Berger MF, Davis MJ, Sawyer A, Pochanard P, Kehoe SM, Johannessen CM, Macconaill LE, Hahn WC, Meyerson M, Garraway LA. J Clin Oncol. 2011 Aug 1;29(22):3085-96 PubMed ID: 21383288

The genomic complexity of primary human prostate cancer
Berger MF, Lawrence MS, Demichelis F, Drier Y, Cibulskis K, Sivachenko AY, Sboner A, Esgueva R, Pflueger D, Sougnez C, Onofrio R, Carter SL, Park K, Habegger L, Ambrogio L, Fennell T, Parkin M, Saksena G, Voet D, Ramos AH, Pugh TJ, Wilkinson J, Fisher S, Winckler W, Mahan S, Ardlie K, Baldwin J, Simons JW, Kitabayashi N, Macdonald TY, Kantoff PW, Chin L, Gabriel SB, Gerstein MB, Golub TR, Meyerson M, Tewari A, Lander ES, Getz G, Rubin MA, Garraway LA. Nature. 2011 Feb 10;470(7333):214-20 PubMed ID: 21307934

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA. Nature. 2010 Dec 16;468(7326):968-72 PubMed ID 21107320

AKT Signaling in Physiology and Disease
Vasudevan KM, Garraway LA. Curr Top Microbiol Immunol. 2011; 347:105-33 PubMed ID 20549472

Integrative analysis of the melanoma transcriptome
Berger MF, Levin JZ, Vijayendran K, Sivachenko A, Adiconis X, Maguire J, Johnson LA, Robinson J, Verhaak RG, Sougnez C, Onofrio RC, Ziaugra L, Cibulskis K, Laine E, Barretina J, Winckler W, Fisher DE, Getz G, Meyerson M, Jaffe DB, Gabriel SB, Lander ES, Dummer R, Gnirke A, Nusbaum C, Garraway LA. Genome Res. 2010 Apr;20(4):413-27. PubMed ID 20179022

An oncogenic role for ETV1 in melanoma
Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA. Cancer Res. 2010; 70(5):2075-84. PubMed ID 20160028

Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts
Levin JZ*, Berger MF*, Adiconis X, Rogov P, Melnikov A, Fennell T, Nusbaum C, Garraway LA, Gnirke A. Genome Biol. 2009; 10(10):R115. PubMed ID 19835606

AKT signaling in physiology and disease
Vasudevan, K.M., Garraway LA. Current Topics in Microbiology and Immunology. In press. Book Chapter.

Stepping on the GAS: a brake pedal for melanoma metastasis?
Linja M, Garraway LA. Pigment Cell Melanoma Res. 2009 Feb; 22(1):8-9. PMID: 19154234

Applications of genomics in melanoma oncogene discovery
Berger MF, Garraway LA. Hematol Oncol Clin North Am. 2009 Jun; 23(3):397-414, vii. Review. PMID: 19464593

p85 Associates with unphosphorylated PTEN and the PTEN-associated complex
Rabinovsky R, Pochanard P, McNear C, Brachmann SM, Duke-Cohan JS, Garraway LA, Sellers WR. Mol Cell Biol. 2009 Oct; 29(19):5377-88. PMID: 19635806

MEK1 mutations confer resistance to MEK and B-RAF inhibition
Emery CM, Vijayendran KG, Zipser MC, Sawyer AM, Niu L, Kim JJ, Hatton C, Chopra R, Oberholzer PA, Karpova MB, MacConaill LE, Zhang J, Gray NS, Sellers WR, Dummer R, Garraway LA. Proc Natl Acad Sci USA. 2009 Dec 1; 106(48):20411-6. Epub 2009 Nov 13. PMID: 19915144

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
Vasudevan, K.M., Barbie, D.A., Davies, M.A., Rabinovsky, R., Hennessy, B.T., Tseng, H., Pochanard, P., Kim, S.Y., Dunn, I.F., Schinzel, A.C., McNear, C.J., Sandy, P., Hoersch, S., Sheng, Q., Gupta, P.B., Boehm, J.S., Reiling, J.H., Silver, S., Lu, Y., Stemke-Hale, K., Dutta, B., Joy, C., Sahin, A.A., Gonzalez-Angulo, A.M., Lluch, A., Rameh, L.E., Jacks, T., Root, D.E., Lander, E.S., Mills, G.B., Hahn, W.C., Sellers, W.R., Garraway, L.A. Cancer Cell. 2009 Jul 7; 16(1):21-32. PMID: 19573809

Modeling genomic diversity and tumor dependency in malignant melanoma
Lin WM, Baker AC, Beroukhim R, Winckler W, Feng W, Marmion JM, Laine E, Greulich H, Tseng H, Gates C, Hodi FS, Dranoff G, Sellers WR, Thomas RK, Meyerson M, Golub TR, Dummer R, Herlyn M, Getz G, Garraway LA. Cancer Res. 2008; 68(3):664-73. PMID: 18245465

High-throughput oncogene mutation profiling in human cancer
Thomas RK, Baker AC, Debiasi RM, Winckler W, Laframboise T, Lin WM, Wang M, Feng W, Zander T, Macconnaill LE, Lee JC, Nicoletti R, Hatton C, Goyette M, Girard L, Majmudar K, Ziaugra L, Wong KK, Gabriel S, Beroukhim R, Peyton M, Barretina J, Dutt A, Emery C, Greulich H, Shah K, Sasaki H, Gazdar A, Minna J, Armstrong SA, Mellinghoff IK, Hodi FS, Dranoff G, Mischel PS, Cloughesy TF, Nelson SF, Liau LM, Mertz K, Rubin MA, Moch H, Loda M, Catalona W, Fletcher J, Signoretti S, Kaye F, Anderson KC, Demetri GD, Dummer R, Wagner S, Herlyn M, Sellers WR, Meyerson M, Garraway LA. Nature Genetics. 2007; 39(3):347-351. PMID: 17293865

Lineage dependency and lineage-survival oncogenes in human cancer
Garraway LA, Sellers WR. Nat Rev Cancer. 2006 Aug; 6(8):593-602. Review. PMID: 16862190

From integrated genomics to tumor lineage dependency
Garraway LA, Sellers WR. Cancer Res. 2006 Mar 1; 66(5):2506-8. Review. PMID: 16510564

"Lineage addiction" in human cancer: lessons from integrated genomics
Garraway LA, Weir BA, Zhao X, Widlund H, Beroukhim R, Berger A, Rimm D, Rubin MA, Fisher DE, Meyerson ML, Sellers WR. Cold Spring Harb Symp Quant Biol. 2005; 70:25-34. PMID: 16869735

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR. Nature. 2005 Jul 7; 436(7047):117-22. PMID: 16001072

PI Publications

Melanoma: from mutations to medicine
Tsao H, Chin L, Garraway LA, Fisher DE. Genes Dev. 2012 Jun 1;26(11):1131-55.

MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma
Wood KC, Konieczkowski DJ, Johannessen CM, Boehm JS, Tamayo P, Botvinnik OB, Mesirov JP, Hahn WC, Root DE, Garraway LA, Sabatini DM. Sci Signal. 2012 May 15;5(224):rs4.

Circumventing cancer drug resistance in the era of personalized medicine
Garraway LA, Jänne PA. Cancer Discovery. 2012 Mar;2(3):214-26

High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes
Choy E, Hornicek F, Macconaill L, Harmon D, Tariq Z, Garraway L, Duan Z. Cancer 2011 Oct 17. [Epub ahead of print]

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion
Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, Boutin AT, Barretina J, Solit DB, Vakiani E, Shao W, Mishina Y, Warmuth M, Jimenez J, Chiang DY, Signoretti S, Kaelin WG, Spardy N, Hahn WC, Hoshida Y, Ogino S, Depinho RA, Chin L, Garraway LA, Fuchs CS, Baselga J, Tabernero J, Gabriel S, Lander ES, Getz G, Meyerson M. Nat Genet. 2011 Sep 4;43(10):964-8

Characterization of the DNA Copy-Number Genome in the Blood of Cutaneous T-Cell Lymphoma Patients
Lin WM, Lewis JM, Filler RB, Modi BG, Carlson KR, Reddy S, Thornberg A, Saksena G, Umlauf S, Oberholzer PA, Karpova M, Getz G, Mane S, Garraway LA, Dummer R, Berger CL, Edelson RL, Girardi M. J Invest Dermatol. 2011 Sep 1. [Epub ahead of print]

Detection of KIAA1549-BRAF Fusion Transcripts in Formalin-Fixed Paraffin-Embedded Pediatric Low-Grade Gliomas
Tian Y, Rich BE, Vena N, Craig JM, Macconaill LE, Rajaram V, Goldman S, Taha H, Mahmoud M, Ozek M, Sav A, Longtine JA, Lindeman NI, Garraway LA, Ligon AH, Stiles CD, Santagata S, Chan JA, Kieran MW, Ligon KL. J Mol Diagn. 2011 Aug 29. [Epub ahead of print]

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Nature. 2011 Aug 18;476(7360):346-50

Nuclear factor I/B is an oncogene in small cell lung cancer
Dooley AL, Winslow MM, Chiang DY, Banerji S, Stransky N, Dayton TL, Snyder EL, Senna S, Whittaker CA, Bronson RT, Crowley D, Barretina J, Garraway L, Meyerson M, Jacks T. Genes Dev. 2011 Jul 15;25(14):1470-5

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
Cheung HW, Cowley GS, Weir BA, Boehm JS, Rusin S, Scott JA, East A, Ali LD, Lizotte PH, Wong TC, Jiang G, Hsiao J, Mermel CH, Getz G, Barretina J, Gopal S, Tamayo P, Gould J, Tsherniak A, Stransky N, Luo B, Ren Y, Drapkin R, Bhatia SN, Mesirov JP, Garraway LA, Meyerson M, Lander ES, Root DE, Hahn WC. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12372-7

Initial genome sequencing and analysis of multiple myeloma
Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M, Anderson KC, Ardlie KG, Auclair D, Baker A, Bergsagel PL, Bernstein BE, Drier Y, Fonseca R, Gabriel SB, Hofmeister CC, Jagannath S, Jakubowiak AJ, Krishnan A, Levy J, Liefeld T, Lonial S, Mahan S, Mfuko B, Monti S, Perkins LM, Onofrio R, Pugh TJ, Rajkumar SV, Ramos AH, Siegel DS, Sivachenko A, Stewart AK, Trudel S, Vij R, Voet D, Winckler W, Zimmerman T, Carpten J, Trent J, Hahn WC, Garraway LA, Meyerson M, Lander ES, Getz G, Golub TR. Nature. 2011 Mar 24;471(7339):467-72

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI. Nature. 2011 Mar 24;471(7339):513-7

High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors towards inhibition of the RAS/RAF/MEK signaling cascade
Kiessling MK, Oberholzer PA, Mondal C, Karpova MB, Zipser MC, Lin WM, Girardi M, Macconaill LE, Kehoe SM, Hatton C, French LE, Garraway LA, Polier G, Süss D, Klemke CD, Krammer PH, Gülow K, Dummer R. Blood. 2011 Feb 24;117(8):2433-40

An Integrated Approach to Uncover Drivers of Cancer
Akavia UD, Litvin O, Kim J, Sanchez-Garcia F, Kotliar D, Causton HC, Pochanard P, Mozes E, Garraway LA, Pe'er D. Cell. 2010 Dec 10;143(6):1005-17

Intronic miR-211 Assumes the Tumor Suppressive Function of Its Host Gene in Melanoma
Levy C, Khaled M, Iliopoulos D, Janas MM, Schubert S, Pinner S, Chen PH, Li S, Fletcher AL, Yokoyama S, Scott KL, Garraway LA, Song JS, Granter SR, Turley SJ, Fisher DE, Novina CD. Mol Cell. 2010 Dec 10;40(5):841-9.

Clinical Implications of the Cancer Genome
Macconaill LE, Garraway LA. J Clin Oncol. 2010 Dec;28(35):5219-28

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy
Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, Beroukhim R, Major JE, Hatton C, Nicoletti R, Hanna M, Sharpe T, Fennell TJ, Cibulskis K, Onofrio RC, Saito T, Shukla N, Lau C, Nelander S, Silver SJ, Sougnez C, Viale A, Winckler W, Maki RG, Garraway LA, Lash A, Greulich H, Root DE, Sellers WR, Schwartz GK, Antonescu CR, Lander ES, Varmus HE, Ladanyi M, Sander C, Meyerson M, Singer S. Nature Genetics. 2010 Aug;42(8):715-21.

On or off target: mutations, models, and predictions
Garraway LA, Hahn WC. Sci Transl Med. 2010 Jun 9;2(35):35ps28.

Recurrent BRAF mutations in Langerhans cell histiocytosis
Badalian-Very G, Vergilio JA, Degar BA, Macconaill LE, Brandner B, Calicchio ML, Kuo FC, Ligon AH, Stevenson KE, Kehoe SM, Garraway LA, Hahn WC, Meyerson M, Fleming MD, Rollins BJ. Blood. 2010 Sept;116(11):1919-23

The landscape of somatic copy-number alteration across multiple human cancer types
Beroukhim R*, Mermel CH*, Porter D, Wei G, Raychaudhuri S, (40 authors) Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M, Letai A, Garraway LA, Loda M, Beer DG, True LD, Okamoto A, Pomeroy SL, Singer S, Golub TR, Lander ES, Getz G, Sellers WR, Meyerson M. Nature. 2010, Feb;463(7283):899-905.

Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set
Park ES, Rabinovsky R, Carey M, Hennessy BT, Agarwal R, Liu W, Ju Z, Deng W, Lu Y, Woo HG, Kim SB, Cheong JH, Garraway LA, Weinstein JN, Mills GB, Lee JS, Davies MA. Mol Cancer Ther. 2010 Feb;9(2):257-67.

Profiling critical cancer gene mutations in clinical tumor samples
MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA. PLoS One. 2009 Nov 18; 4(11):e7887.

Oncogenic activating mutations are associated with local copy gain
Modrek B, Ge L, Pandita A, Lin E, Mohan S, Yue P, Guerrero S, Lin WM, Pham T, Modrusan Z, Seshagiri S, Stern HM, Waring P, Garraway LA, Chant J, Stokoe D, Cavet G. Mol Cancer Res. 2009 Aug; 7(8):1244-52.

Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions
Sos ML, Michel K, Zander T, Weiss J, Frommolt P, Peifer M, Li D, Ullrich R, Koker M, Fischer F, Shimamura T, Rauh D, Mermel C, Fischer S, Stückrath I, Heynck S, Beroukhim R, Lin W, Winckler W, Shah K, LaFramboise T, Moriarty WF, Hanna M, Tolosi L, Rahnenführer J, Verhaak R, Chiang D, Getz G, Hellmich M, Wolf J, Girard L, Peyton M, Weir BA, Chen TH, Greulich H, Barretina J, Shapiro GI, Garraway LA, Gazdar AF, Minna JD, Meyerson M, Wong KK, Thomas RK. J Clin Invest. 2009 Jun; 119(6):1727-40.

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR
Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, Seeger JM, Weiss J, Fischer F, Frommolt P, Michel K, Peifer M, Mermel C, Girard L, Peyton M, Gazdar AF, Minna JD, Garraway LA, Kashkar H, Pao W, Meyerson M, Thomas RK. Cancer Res. 2009 Apr 15; 69(8):3256-61.

Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation
Salvesen HB, Carter SL, Mannelqvist M, Dutt A, Getz G, Stefansson IM, Raeder MB, Sos ML, Engelsen IB, Trovik J, Wik E, Greulich H, Bø TH, Jonassen I, Thomas RK, Zander T, Garraway LA, Oyan AM, Sellers WR, Kalland KH, Meyerson M, Akslen LA, Beroukhim R. Proc Natl Acad Sci USA. 2009 Mar 24; 106(12):4834-9.

Comprehensive genomic characterization defines human glioblastoma genes and core pathways
Cancer Genome Atlas Research Network. Nature. 2008 Oct 23;455(7216):1061-8.

Major copy proportion analysis of tumor samples using SNP arrays
Li C, Beroukhim R, Weir BA, Winckler W, Garraway LA, Sellers WR, Meyerson M. BMC Bioinformatics. 2008 Apr 21; 9:204.

SNP panel identification assay (SPIA): a genetic-based assay for the identification of cell lines
Demichelis F, Greulich H, Macoska JA, Beroukhim R, Sellers WR, Garraway L, Rubin MA. Nucleic Acids Res. 2008; 36(7):2446-56.

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma
Beroukhim R, Getz G, Nghiemphu L, Barretina J, Hsueh T, Linhart D, Vivanco I, Lee JC, Huang JH, Alexander S, Du J, Kau T, Thomas RK, Shah K, Soto H, Perner S, Prensner J, Debiasi RM, Demichelis F, Hatton C, Rubin MA, Garraway LA, Nelson SF, Liau L, Mischel PS, Cloughesy TF, Meyerson M, Golub TA, Lander ES, Mellinghoff IK, Sellers WR. Proc Natl Acad Sci USA. 2007 Dec 11; 104(50):20007-12.

Characterizing the cancer genome in lung adenocarcinoma
Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M. Nature. 2007 Dec 6; 450(7171):893-8.

A 2-Mb critical region implicated in the microcephaly associated with terminal 1q deletion syndrome
Hill AD, Chang BS, Hill RS, Garraway LA, Bodell A, Sellers WR, Walsh CA. Am J Med Genet A. 2007 Aug 1; 143A(15):1692-8.

Integrative genomic approaches identify IKBKE as a breast cancer oncogene
Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC. Cell. 2007 Jun 15; 129(6):1065-79.

Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models
Ji H, Wang Z, Perera SA, Li D, Liang MC, Zaghlul S, McNamara K, Chen L, Albert M, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Thomas RK, Garraway LA, Jänne PA, Johnson BE, Chin L, Wong KK. Cancer Res. 2007 May 15; 67(10):4933-9.

Malignant melanoma: genetics and therapeutics in the genomic era
Chin L, Garraway LA, Fisher DE. Genes Dev. 2006 Aug 15; 20(16):2149-82. Review.

Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing
Thomas RK, Nickerson E, Simons JF, Jänne PA, Tengs T, Yuza Y, Garraway LA, LaFramboise T, Lee JC, Shah K, O'Neill K, Sasaki H, Lindeman N, Wong KK, Borras AM, Gutmann EJ, Dragnev KH, DeBiasi R, Chen TH, Glatt KA, Greulich H, Desany B, Lubeski CK, Brockman W, Alvarez P, Hutchison SK, Leamon JH, Ronan MT, Turenchalk GS, Egholm M, Sellers WR, Rothberg JM, Meyerson M. Nat Med. 2006 Jul;12(7):852-5.

Androgen-dependent regulation of Her-2/neu in prostate cancer cells
Berger R, Lin DI, Nieto M, Sicinska E, Garraway LA, Adams H, Signoretti S, Hahn WC, Loda M. Cancer Res. 2006 Jun 1; 66(11):5723-8.

BRAF mutation predicts sensitivity to MEK inhibition
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N. Nature. 2006;439(7074):358-62.

Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays
Beroukhim R, Lin M, Park Y, Hao K, Zhao X, Garraway LA, Fox EA, Hochberg EP, Mellinghoff IK, Hofer MD, Descazeaud A, Rubin MA, Meyerson M, Wong WH, Sellers WR, Li C. PLoS Comput Biol. 2006 May; 2(5):e41.

BRAF mutation predicts sensitivity to MEK inhibition
Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N. Nature. 2006 Jan 19; 439(7074):358-62.

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis
Zhao X, Weir BA, LaFramboise T, Lin M, Beroukhim R, Garraway L, Beheshti J, Lee JC, Naoki K, Richards WG, Sugarbaker D, Chen F, Rubin MA, Jänne PA, Girard L, Minna J, Christiani D, Li C, Sellers WR, Meyerson M. Cancer Res. 2005;65(13):5561-70.

Intermediate basal cells of the prostate: in vitro and in vivo characterization
Garraway LA, Lin D, Signoretti S, Waltregny D, Dilks J, Bhattacharya N, Loda M. Prostate. 2003 May 15; 55(3):206-18.

p63 is a prostate basal cell marker and is required for prostate development
Signoretti S, Waltregny D, Dilks J, Isaac B, Lin D, Garraway L, Yang A, Montironi R, McKeon F, Loda M. Am J Pathol. 2000;157(6):1769-75.

Funding

Melanoma Research Alliance
National Cancer Institute
Robert Wood Johnson Foundation
The Burroughs-Wellcome Fund
The National Institute for Human Genome
Novartis Institute for Biomedical Research
Prostate Cancer Foundation
Adelson Medical Research Foundation
Dana Farber/Harvard Cancer Center
Starr Cancer Consortium
Harry J. Lloyd Charitable Trust
US Department of Defense